Compound Q&A
How is N~6~-[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-N~2~-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine (CAS: 204777-78-6) typically synthesized?
Answer
![N~6~-[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-N~2~-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine](https://static.chemtradehub.com/structs/204/204777-78-6-8d7c.webp "N~6~-[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-N~2~-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine")
N~6~-[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-N~2~-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine is synthesized through multistep reactions involving coupling of a fluorenylmethyloxycarbonyl (FMOC) protected amino acid with a specific cyclohexanone derivative. The synthesis typically requires the use of coupling agents like HATU and bases such as DIPEA. The yield and selectivity can be improved by optimizing reaction conditions and using appropriate protecting groups.
About
CAS No
204777-78-6
English Name
N~6~-[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-N~2~-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-lysine
Molecular Formula
C34H42N2O6
Molecular Weight
574.72 g/mol
SMILES
CC(C)CC(=NCCCCC(C(=O)O)NC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)C4=C(CC(CC4=O)(C)C)O
InChIKey
PYCBVLUBTMHNPW-MHZLTWQESA-N
Last Updated: 2025-09-07 10:18
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