Compound Q&A

How is Butyl salicylate (CAS: 2052-14-4) typically synthesized?

Answer

Butyl salicylate
Butyl salicylate (CAS: 2052-14-4) is typically synthesized by esterification of salicylic acid with n-butanol in the presence of a strong acid catalyst, such as sulfuric acid or hydrochloric acid. The reaction is carried out under reflux conditions, and the mixture is then neutralized to obtain the desired product. The yield of the reaction is around 85-90%, and the method is selective towards the butyl ester formation.

About

CAS No 2052-14-4
English Name Butyl salicylate
Molecular Formula C11H14O3
Molecular Weight 194.23 g/mol
SMILES CCCCOC(=O)c1ccccc1O
InChIKey YFDUWSBGVPBWKF-UHFFFAOYSA-N
Last Updated: 2025-09-07 10:18

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