Compound Q&A
How is 2-Isobutyl-1,3-thiazole (CAS: 18640-74-9) typically synthesized?
Answer
2-Isobutyl-1,3-thiazole (CAS: 18640-74-9) is commonly synthesized via the thiazole coupling reaction between isobutylamine and 2-bromo-4,6-dichloropyrimidine. The reaction is catalyzed by palladium(II) acetate and a ligand such as Xantphos. The yield is around 75-85%, and the method provides good regioselectivity and chemoselectivity.
About
CAS No
18640-74-9
English Name
2-Isobutyl-1,3-thiazole
Molecular Formula
C7H11NS
Molecular Weight
141.24 g/mol
SMILES
CC(C)Cc1nccs1
InChIKey
CMPVUVUNJQERIT-UHFFFAOYSA-N
Last Updated: 2025-09-07 10:18
