Compound Q&A
How is Ethyl 4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-1-piperazinecarboxylate (CAS: 67914-69-6) typically synthesized?
Answer
![Ethyl 4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-1-piperazinecarboxylate](https://static.chemtradehub.com/structs/679/67914-69-6-68b0.webp "Ethyl 4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-1-piperazinecarboxylate")
Ethyl 4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-1-piperazinecarboxylate (CAS: 67914-69-6) is typically synthesized using a multi-step process involving protection of the piperazine group, introduction of the 2,4-dichlorophenyl group, and subsequent coupling with the imidazol-1-ylmethyl-1,3-dioxolan-4-yl moiety. The synthesis involves the use of catalytic amounts of acetic acid and a protecting group for the piperazine, followed by deprotection and coupling under basic conditions.
About
CAS No
67914-69-6
English Name
Ethyl 4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)-1-piperazinecarboxylate
Molecular Formula
C27H30Cl2N4O5
Molecular Weight
561.47 g/mol
SMILES
CCOC(=O)N1CCN(CC1)c2ccc(cc2)OC[C@H]3CO[C@](O3)(Cn4ccnc4)c5ccc(cc5Cl)Cl
InChIKey
VEVFSWCSRVJBSM-HOFKKMOUSA-N
Last Updated: 2025-09-07 10:18