Compound Q&A
What is Afatinib Impurity 51 (CAS: 314771-76-1)?
Answer
Afatinib Impurity 51 is a byproduct found in the synthetic process of afatinib, a broad-spectrum tyrosine kinase inhibitor used in the treatment of non-small cell lung cancer and head and neck cancer. Its chemical formula is C21H17F3N2O2. This impurity has similar physical properties to the parent compound, including a yellow solid at room temperature and a melting point range of 167-169°C.
About
CAS No
314771-76-1
English Name
Afatinib Impurity 51
Molecular Formula
C18H16ClFN4O2
Molecular Weight
374.8 g/mol
SMILES
FC1=CC=C(NC2=C3C=C(N)C(O[C@@H]4COCC4)=CC3=NC=N2)C=C1Cl
InChIKey
BIQABKFYKJRXII-NSHDSACASA-N
Last Updated: 2025-09-04 23:41
