3-(3,4-DICHLOROPHENYL)-PYRAZOLE-5-CARBOXYLIC ACID(CAS: 276684-04-9)

5-(3,4-Dichlorophenyl)-1H-pyrazole-3-carboxylic acid is a white to off-white solid with a molecular weight of 263.04 g/mol. It is poorly soluble in water but soluble in organic solvents like DMSO. The compound is known for its acidity and can form salts with bases. It is stable under normal conditions but reacts with strong reducing agents.

5-(3,4-Dichlorophenyl)-1H-pyrazole-3-carboxylic acid is usually synthesized via the condensation of 3,4-dichlorophenyl isocyanate with 1H-pyrazole-3-carboxylic acid hydrazide. The reaction is carried out in an aprotic solvent such as dimethylformamide (DMF) in the presence of a base like triethylamine. The yield is typically around 70-80%.

5-(3,4-Dichlorophenyl)-1H-pyrazole-3-carboxylic acid finds applications in the pharmaceutical industry due to its potential as an intermediate in drug synthesis. It is also used in the development of sensors and as a component in certain polymer formulations.

When handling 5-(3,4-Dichlorophenyl)-1H-pyrazole-3-carboxylic acid, wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure the work is conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate methods, and the material safety data sheet (MSDS) should be consulted for specific disposal instructions. It is also important to avoid contact with eyes and ingestion.