4,6-Dichloro-N,N-dimethyl-2-pyrimidinamine(CAS: 5734-68-9)

4,6-Dichloro-N,N-dimethyl-2-pyrimidinamine is a white to off-white crystalline solid. Its molecular weight is approximately 212.04 g/mol. The compound has a low water solubility of 0.01 g/100 mL at 25°C. It is relatively stable under normal conditions but can react with strong bases or acids. It is also a potent inhibitor of dihydrofolate reductase, which makes it useful in pharmacological research.

4,6-Dichloro-N,N-dimethyl-2-pyrimidinamine is typically synthesized by the nucleophilic substitution of 2-chloropyrimidine with dimethylamine. Common methods involve using dimethylamine in acetic acid solution at room temperature. The reaction is selective and yields up to 90% of the desired product. The use of a catalyst such as sodium acetate can enhance the reaction selectivity and yield.

4,6-Dichloro-N,N-dimethyl-2-pyrimidinamine is primarily used in pharmaceuticals for its antifolate activity. It is also utilized in semiconductors for doping purposes and in the development of sensors due to its optical properties. Additionally, it has potential applications in agrochemicals and as a research tool in organic chemistry.

When handling 4,6-Dichloro-N,N-dimethyl-2-pyrimidinamine, it is important to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Ensure the compound is handled in a well-ventilated area or a fume hood to avoid inhalation of its dust or fumes. Spills should be cleaned up using appropriate absorbents and disposed of according to local regulations. Always consult the safety data sheet (SDS) for detailed information on handling and disposal.