Anastrozole EP Impurity D(CAS: 1027160-12-8)

Anastrozole EP Impurity D (CAS: 1027160-12-8) is a white to off-white crystalline solid with a molecular weight of approximately 325.36 g/mol. It has a solubility of 10 mg/L in water and is relatively stable under normal conditions. This impurity is typically an amide-based compound with limited reactivity under standard laboratory conditions.

Anastrozole EP Impurity D (CAS: 1027160-12-8) is synthesized via a multistep process involving amidation and reduction reactions. Commonly, this involves the amidation of 4-methyl-2,6-dichlorophenol with an appropriate amine followed by selective reduction to form the desired impurity. This process requires precise control over reaction conditions to achieve high yield and selectivity.

Anastrozole EP Impurity D (CAS: 1027160-12-8) is primarily used in the pharmaceutical industry as an impurity in the synthesis and purification of anastrozole, a hormone therapy used for treating breast cancer. It is not commonly used in other industries such as polymers, sensors, or semiconductors due to its specific application in pharmaceuticals.

When handling Anastrozole EP Impurity D (CAS: 1027160-12-8), it is essential to use appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Ensure that all operations are conducted in a well-ventilated area or a fume hood to minimize inhalation risks. In case of a spill, immediately clean up using appropriate absorbent materials and follow the safety data sheet (SDS) guidelines for disposal.