1H-Indol-7-yl(phenyl)methanone(CAS: 70803-96-2)

1H-Indol-7-yl(phenyl)methanone is a crystalline compound with a molecular weight of approximately 252.27 g/mol. It has a low solubility in water but is more soluble in organic solvents like dichloromethane and ethanol. Chemically, it exhibits moderate reactivity, particularly towards nucleophilic substitution and oxidation reactions.

1H-Indol-7-yl(phenyl)methanone is typically synthesized via the condensation of indole with phenylmethanol in the presence of a Lewis acid catalyst such as aluminum trichloride or zinc bromide. The reaction is carried out under reflux conditions, and the yield can be up to 85%.

1H-Indol-7-yl(phenyl)methanone is used in the pharmaceutical industry for the development of certain drugs, and it has potential applications in the polymer industry for creating advanced materials. It is also explored in the field of sensors and semiconductors for its unique electronic properties.

When handling 1H-Indol-7-yl(phenyl)methanone, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be properly ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.