1-Bromo-3-fluoro-5-methylbenzene(CAS: 202865-83-6)

1-Bromo-3-fluoro-5-methylbenzene is a white crystalline solid with a molecular weight of approximately 223.04 g/mol. It has a melting point of 64-66°C and a boiling point of 214-216°C. The compound is slightly soluble in water but more soluble in organic solvents like methanol and dichloromethane. Chemically, it is relatively stable but can undergo electrophilic aromatic substitution reactions. It has a bromine atom, a fluoro group, and a methyl group substituent on the benzene ring.

1-Bromo-3-fluoro-5-methylbenzene can be synthesized from bromination of 3-fluoro-5-methylbenzene using bromine in the presence of a Lewis acid catalyst such as aluminum bromide. The reaction is typically carried out in a chlorinated solvent like dichloromethane. The yield is around 70-80%, and the selectivity towards the bromination product is high due to the ortho and para directing effects of the methyl and fluoro substituents.

1-Bromo-3-fluoro-5-methylbenzene is primarily used in the pharmaceutical and chemical industries. It serves as a precursor for the synthesis of various drugs and intermediates. In the polymer industry, it can be used in the production of speciality polymers. Additionally, it has potential applications in the development of sensors and electronic materials due to its unique chemical structure.

When handling 1-Bromo-3-fluoro-5-methylbenzene, appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The compound should be handled in a well-ventilated area or under a fume hood due to potential evaporation and inhalation risks. In case of a spill, the area should be cleaned immediately using appropriate chemical waste disposal procedures. Always refer to the Safety Data Sheet (SDS) for specific handling and emergency information. Storage should be in a cool, dark, and dry place, away from incompatible materials.