1-Chloro-3-methylisoquinoline(CAS: 7115-16-4)

1-Chloro-3-methylisoquinoline (CAS: 7115-16-4) is a crystalline compound with a molecular weight of approximately 172.6 g/mol. It has a solubility in water of 0.01 g/100 mL. The compound is moderately reactive, particularly with nucleophiles. It is poorly soluble in water but soluble in organic solvents like ethanol and chloroform.

1-Chloro-3-methylisoquinoline (CAS: 7115-16-4) can be synthesized via the chlorination of 3-methylisoquinoline using thionyl chloride as the chlorinating agent. This method provides good selectivity and yield. Alternatively, it can be prepared from 1-methylisoquinoline via a chlorination reaction with a Lewis acid such as aluminum chloride.

1-Chloro-3-methylisoquinoline (CAS: 7115-16-4) is primarily used in the pharmaceutical industry for the synthesis of certain medicinal compounds. It is also of interest in the chemical industry for its potential applications in the development of new polymers and as a precursor in organic synthesis.

When handling 1-Chloro-3-methylisoquinoline (CAS: 7115-16-4), it is important to use proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up carefully using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed handling instructions.