methyl 3-chloro-2,2-dimethyl-3-oxopropanoate(CAS: 64507-20-6)

Methyl 3-chloro-2,2-dimethyl-3-oxopropanoate is a colorless to pale yellow liquid at room temperature. It has a molecular weight of approximately 160.58 g/mol. The compound is slightly soluble in water but soluble in common organic solvents like ethanol, acetone, and dichloromethane. It is known for its reactivity towards nucleophiles, particularly chloride displacement reactions.

Methyl 3-chloro-2,2-dimethyl-3-oxopropanoate is usually synthesized via the substitution of the methyl group in 2,2-dimethyl-3-oxopropanoic acid with a chlorine atom. This can be achieved using thionyl chloride in the presence of a base like pyridine or triethylamine. The reaction is typically carried out in a solvent like dichloromethane or toluene, yielding a high yield of the target compound.

Methyl 3-chloro-2,2-dimethyl-3-oxopropanoate is utilized in various industries. It serves as an intermediate in the synthesis of pharmaceuticals, particularly analgesics and antipyretics. Additionally, it is used in the production of polymers and as a building block in the development of chemical sensors and materials for electronic applications.

When handling methyl 3-chloro-2,2-dimethyl-3-oxopropanoate, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood to minimize exposure to volatile organic compounds. Spills should be addressed promptly using appropriate spill cleanup materials. Always consult the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.