Baricitinib Impurity 10(CAS: 1029716-44-6)

Baricitinib Impurity 10 is a crystalline compound with a molecular weight of approximately 375.37 g/mol. It is poorly water-soluble, with a solubility of about 0.01 g/L. Physically, it appears as a white to off-white solid. Chemically, it is reactive towards strong acids and bases. It is stable under normal storage conditions but requires protection from moisture and light to maintain its purity.

Baricitinib Impurity 10 is typically synthesized through a multi-step process involving organic transformations such as Friedel-Crafts alkylation and selective hydrogenation. The synthesis involves the use of catalytic systems and careful temperature control to achieve high selectivity and yield. The process is optimized to minimize the formation of this impurity.

Baricitinib Impurity 10 (CAS: 1029716-44-6) is primarily used in the pharmaceutical industry, specifically in the development and quality control of baricitinib, a JAK inhibitor used in the treatment of rheumatoid arthritis. It is also of interest in research settings for its pharmacological properties.

When handling Baricitinib Impurity 10 (CAS: 1029716-44-6), it is important to use personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency procedures.