4-Amino-2-hydroxybenzonitrile(CAS: 67608-58-6)

4-Amino-2-hydroxybenzonitrile is a white or off-white crystalline solid with a molecular weight of approximately 196.16 g/mol. It is slightly soluble in water and ethanol, and has a low solubility in non-polar solvents. Chemically, it is mildly reactive, particularly in the presence of bases or reducing agents.

4-Amino-2-hydroxybenzonitrile is typically synthesized via the reaction of 2-hydroxybenzoyl chloride with ammonia in the presence of a base. The reaction is conducted in an aprotic solvent like dichloromethane, and yields are generally around 80-90%. The use of appropriate catalysts can enhance selectivity and reaction efficiency.

4-Amino-2-hydroxybenzonitrile is used in the pharmaceutical industry for the synthesis of certain drug compounds. It also has applications in the production of dyes and pigments, and can be utilized in the development of sensors and semiconductors due to its functional groups.

When handling 4-Amino-2-hydroxybenzonitrile, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be done in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly rinsed. Always consult the Safety Data Sheet (SDS) for detailed safety information.