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Omarigliptin(CAS: 1226781-44-7)
CAS Number
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Basic Information
Molecular Formula
C17H20F2N4O3S
Molecular Weight
398.44 g/mol
Chemical Identifiers
SMILES
CS(=O)(=O)N1C=C2CN(CC2=N1)C3CC(C(OC3)C4=C(C=CC(=C4)F)F)N
InChIKey
MKMPWKUAHLTIBJ-ISTRZQFTSA-N
Database References
MDL Number
MFCD22573261
FAQ
Omarigliptin is a crystalline compound with a molecular weight of approximately 330.35 g/mol. It is slightly soluble in water and ethanol. Omarigliptin is relatively stable under normal conditions but reacts with strong oxidizing agents. It has a melting point of 130-132°C. The compound shows low reactivity towards common organic reagents.
Omarigliptin is synthesized via a multi-step process involving protection/deprotection steps and key functional group transformations. The key reaction is a Michael addition followed by a hydrolysis step. The synthesis typically employs catalytic amounts of palladium and uses a solvent like acetonitrile. The overall yield is around 70% with good selectivity.
Omarigliptin is primarily used in the pharmaceutical industry. It is a DPP-4 inhibitor used in the treatment of type 2 diabetes. Additionally, it has potential applications in the development of other therapeutic agents for metabolic disorders. Omarigliptin is not widely used in other industries such as polymers, sensors, or semiconductors.
When handling Omarigliptin, appropriate personal protective equipment (PPE) such as gloves and goggles should be worn. Work should be conducted in a well-ventilated area or with the use of a fume hood. Spills should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS/SDS) for detailed safety information and emergency procedures.
Safety Notice
Please verify product specifications and safety data before use. Contact the supplier for detailed safety information.
Always follow proper handling procedures
