4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile(CAS: 1197377-47-1)

4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile is a crystalline compound with a molecular weight of approximately 237.07 g/mol. It has a low solubility in water but is more soluble in organic solvents like DMF and DMSO. The compound is relatively stable in acidic conditions but can react with bases to form amine derivatives. It is also known for its reactivity in nucleophilic substitution reactions.

4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile is typically synthesized by the reaction of 2-fluorobenzonitrile with 1,2,4-triazine-3(2H)-thione in the presence of a suitable base such as sodium hydride. The reaction is carried out at room temperature, and the product can be isolated by recrystallization from an appropriate solvent. The yield is usually around 70-80%, with excellent selectivity and purity.

4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile is primarily used in the pharmaceutical industry for the synthesis of various medicinal compounds. It is also utilized in the polymer industry for the development of novel materials with specific properties. Additionally, it has applications in the production of sensors and semiconductors due to its unique electronic and chemical characteristics.

When handling 4-(3-Amino-1,2,4-triazin-6-yl)-2-fluorobenzonitrile, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight. Fume hoods should be used during handling to minimize inhalation. Spills should be cleaned up immediately using appropriate absorbent materials. Always consult the Material Safety Data Sheet (MSDS) for detailed handling and safety information.