1-(4-Chlorophenyl)-2-cyclopropyl-1-propanone(CAS: 123989-29-7)

1-(4-Chlorophenyl)-2-cyclopropyl-1-propanone is a white crystalline powder with a molecular weight of approximately 222.6 g/mol. It has a low water solubility and is soluble in organic solvents such as acetone and dichloromethane. The compound is known for its good reactivity in ketone chemistry and can undergo various transformations in the presence of appropriate reagents.

1-(4-Chlorophenyl)-2-cyclopropyl-1-propanone can be synthesized via a Claisen-Schmidt condensation between 4-chlorobenzaldehyde and cyclopropylmethyl ketone. The reaction is typically catalyzed by a base such as sodium hydroxide, and the product is isolated by recrystallization. The yield can be up to 80% with high selectivity.

1-(4-Chlorophenyl)-2-cyclopropyl-1-propanone finds applications in the pharmaceutical industry, where it is used as an intermediate in the synthesis of certain drugs. It is also utilized in the polymer industry for the development of new materials and in the chemical sensors sector for gas detection applications.

When handling 1-(4-Chlorophenyl)-2-cyclopropyl-1-propanone, it is essential to use appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Spills should be handled in a fume hood using a suitable absorbent material. This compound may irritate the skin and eyes, so immediate washing with water is recommended if contact occurs. Always refer to the Safety Data Sheet (SDS) for detailed safety information.