7-Chloro-4-hydroxy-2,3-dihydro-1H-inden-1-one(CAS: 24425-39-6)

7-Chloro-4-hydroxy-2,3-dihydro-1H-inden-1-one is a crystalline solid at room temperature with a molecular weight of approximately 219.01 g/mol. It has a solubility of about 0.05 g/100 mL in water and is soluble in common organic solvents like ethanol and acetone. The compound is moderately reactive, particularly towards nucleophiles. It is stable under normal conditions but should be stored away from direct sunlight and moisture.

7-Chloro-4-hydroxy-2,3-dihydro-1H-inden-1-one is typically synthesized via a multistep process involving the chlorination of 4-hydroxy-2,3-dihydro-1H-inden-1-one, followed by subsequent oxidation or other functionalization steps. The reaction is carried out using reagents like thionyl chloride and a catalyst. The synthesis yields are generally good, with a moderate to high degree of selectivity.

7-Chloro-4-hydroxy-2,3-dihydro-1H-inden-1-one is used in the pharmaceutical industry for the synthesis of various drug candidates, particularly those involving indenone derivatives. It also finds applications in the polymer industry for the development of advanced materials. Additionally, it has potential uses in the production of sensors and semiconductors due to its chemical properties.

When handling 7-Chloro-4-hydroxy-2,3-dihydro-1H-inden-1-one, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure that the work is done in a fume hood to minimize exposure to the compound. In case of a spill, wet the spill area with water to dilute the compound and report it to the safety officer. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.