3-(4-Bromophenyl)-5-methyl-1H-pyrazole(CAS: 145353-53-3)

3-(4-Bromophenyl)-5-methyl-1H-pyrazole (CAS: 145353-53-3) is a crystalline solid with a molecular weight of approximately 222.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like dimethylformamide (DMF) and dimethyl sulfoxide (DMSO). The compound is moderately reactive and can undergo substitution reactions. It is stable under normal storage conditions but should be protected from moisture and light.

3-(4-Bromophenyl)-5-methyl-1H-pyrazole can be synthesized through a multistep process involving bromination of an aromatic ring followed by a condensation reaction. Commonly, bromobenzene is brominated using N-bromosuccinimide (NBS) or N-iodosuccinimide (NIS) in the presence of a radical initiator. Subsequently, the bromobenzene derivative is treated with a pyrazole ring precursor, such as 1,3-dimethylpyrazole, in an appropriate solvent like dichloromethane or toluene under reflux conditions.

3-(4-Bromophenyl)-5-methyl-1H-pyrazole (CAS: 145353-53-3) is primarily used in the pharmaceutical industry for the development of drug candidates. It is also utilized in the polymer industry for modifying polymer properties and in the sensor industry for detecting specific analytes. Additionally, it is explored in semiconductor applications for its electronic properties.

3-(4-Bromophenyl)-5-methyl-1H-pyrazole (CAS: 145353-53-3) should be handled in a well-ventilated area and preferably in a fume hood due to its potential to react with moisture. It is recommended to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coat. Spills should be cleaned up using appropriate absorbent materials and the area should be flushed with water. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.