Boc-NH-PEG7-acid(CAS: 2055044-68-1)

Boc-NH-PEG7-acid (CAS: 2055044-68-1) is a polyethylene glycol derivative with a molecular weight around 1221 Da. It is a white or off-white solid with a crystalline form. This compound has low solubility in water but is soluble in organic solvents. It is reactive towards carboxylic acids and amine groups, making it useful in conjugation reactions. Its physical properties include a melting point of approximately 150-160°C and a density of about 1.1 g/cm³.

Boc-NH-PEG7-acid is typically synthesized by reacting Boc-amine with polyethylene glycol (PEG) of 7,000 molecular weight in the presence of a coupling agent such as 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and N-hydroxysuccinimide (NHS). The reaction occurs under anhydrous conditions and is optimized for high yield. The product is purified by precipitation from organic solvents and drying.

Boc-NH-PEG7-acid (CAS: 2055044-68-1) is widely used in pharmaceuticals for conjugating proteins and peptides, in polymer science for creating polymeric materials, in sensor technology for biosensing applications, and in the semiconductor industry for manufacturing processes. It is also applied in the development of drug delivery systems and in academic research for various chemical and biological studies.

When handling Boc-NH-PEG7-acid (CAS: 2055044-68-1), it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Operations should be performed in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately with appropriate absorbent materials. Always refer to the safety data sheet (SDS) for detailed handling and disposal information and ensure that all waste is disposed of according to local regulations.