4-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine(CAS: 1227270-73-6)

4-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine is a solid with a crystalline form. Its molecular weight is approximately 284.32 g/mol. It is poorly soluble in water but soluble in organic solvents like dichloromethane and ethanol. The compound is stable under normal laboratory conditions but reacts with strong bases and reducing agents. It has a low volatility and is not flammable.

4-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine can be synthesized through a multi-step process involving the coupling of 4-methyl-1H-pyrrolo[2,3-b]pyridine with phenylsulfonyl chloride. The reaction is typically carried out in the presence of a base like triethylamine and a solvent such as dichloromethane. The yield is around 70-80%, and the product is isolated by column chromatography.

4-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine is used in the pharmaceutical and chemical industries. It serves as an intermediate in the synthesis of various pharmaceutical compounds, particularly in the development of anti-inflammatory and analgesic drugs. It is also used in the preparation of materials for sensors and semiconductors due to its unique electronic properties.

When handling 4-Methyl-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine, it is recommended to use appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. The compound should be used in a well-ventilated area or a fume hood. Spills should be cleaned up using appropriate solid absorbents and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal information.