2,5-Dibromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine(CAS: 852228-17-2)

2,5-Dibromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is a crystalline solid with a molecular weight of approximately 378.06 g/mol. It has low solubility in water but is soluble in common organic solvents such as dichloromethane and acetone. Chemically, it is reactive towards nucleophiles and can participate in various boron-mediated reactions. It is used in the synthesis of complex organic molecules and as a building block in asymmetric synthesis.

2,5-Dibromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is typically synthesized using palladium-catalyzed cross-coupling reactions. Common methods involve the reaction of 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine with bromopyridine in the presence of a palladium catalyst and a boronate ester. This process provides good selectivity and high yield under mild conditions.

2,5-Dibromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine is primarily used in the pharmaceutical and polymer industries for the synthesis of complex organic molecules and polymers. It also finds applications in the development of sensors and semiconductors due to its unique chemical properties.

When handling 2,5-Dibromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, it is essential to use personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up according to the Material Safety Data Sheet (MSDS/SDS) guidelines. Ensure proper ventilation and avoid inhalation or skin contact. Always follow all safety protocols and refer to the latest SDS for detailed information.