1-[(2S)-3-(Acetylsulfanyl)-2-methylpropanoyl]-L-prolyl-L-phenylalanine(CAS: 74258-86-9)

1-[(2S)-3-(Acetylsulfanyl)-2-methylpropanoyl]-L-prolyl-L-phenylalanine is a crystalline compound with a molecular weight of approximately 431.5 g/mol. It has a low solubility in water (0.03 g/100 mL at 25°C) and moderate solubility in organic solvents like methanol and acetonitrile. The compound is relatively stable under normal conditions but can react with strong bases and acids. It shows high reactivity towards nucleophiles in certain organic reactions.

This compound is typically synthesized through a multi-step process involving the coupling of acetylthiomethyl acetate with L-prolyl-L-phenylalanine. Commonly, a coupling reagent like HATU (O-(7-azabenzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate) is used. The reaction is typically carried out in the presence of a base such as diisopropylethylamine (DIPEA) in an organic solvent like N,N-dimethylformamide (DMF). The yield is generally around 50-60%.

This compound is primarily used in the pharmaceutical industry for the development of specific drug candidates due to its unique chemical structure. It may also find applications in the polymer and materials science industries, particularly in the synthesis of advanced polymers and sensors. Additionally, it can be used in the semiconductor industry for various specialized applications.

When handling 1-[(2S)-3-(Acetylsulfanyl)-2-methylpropanoyl]-L-prolyl-L-phenylalanine, it is essential to wear appropriate Personal Protective Equipment (PPE) such as lab coat, gloves, and safety goggles. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. Spills should be handled using appropriate absorbent materials and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.