2-Bromo-1-(4-chlorophenyl)-1-propanone(CAS: 877-37-2)

2-Bromo-1-(4-chlorophenyl)-1-propanone is a crystalline solid with a molecular weight of approximately 247.02 g/mol. It is slightly soluble in water but more soluble in organic solvents like ethanol and acetone. The compound is relatively stable but can react with strong nucleophiles and bases. It has a melting point of around 78-80°C and a boiling point of approximately 250-255°C at 760 mmHg.

2-Bromo-1-(4-chlorophenyl)-1-propanone is typically synthesized via a bromination reaction of 1-(4-chlorophenyl)-1-propanone using N-bromosuccinimide (NBS) as a brominating agent in the presence of a radical initiator like azobisisobutyronitrile (AIBN). The reaction yields a product with high selectivity and good yield, making it a suitable method for industrial production.

2-Bromo-1-(4-chlorophenyl)-1-propanone is used primarily in the pharmaceutical industry as an intermediate for the synthesis of various drugs. It is also employed in the polymer industry for the production of special polymers and in the sensor industry for developing chemical sensors. Additionally, it has applications in the semiconductor industry for specific cleaning processes.

When handling 2-Bromo-1-(4-chlorophenyl)-1-propanone, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure. Spills should be handled carefully using appropriate absorbents, and the area should be thoroughly cleaned. Always consult the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.