Ammonium 4-(acetoacetylamino)-5-methoxy-2-methylbenzenesulfonate(CAS: 72705-22-7)

Ammonium 4-(acetoacetylamino)-5-methoxy-2-methylbenzenesulfonate is a white crystalline solid with a molecular weight of approximately 408.45 g/mol. It is sparingly soluble in water and ethanol. Chemically, it is relatively stable under normal conditions but can react with strong acids to form the corresponding sulfonate. It has a melting point around 155-157°C and a density of 1.38 g/cm³.

Ammonium 4-(acetoacetylamino)-5-methoxy-2-methylbenzenesulfonate is synthesized via the reaction of 4-(acetoacetylamino)-5-methoxy-2-methylbenzenesulfonyl chloride with ammonium hydroxide. The process involves the condensation of the sulfonyl chloride with the amino group, followed by the neutralization with ammonia, yielding the desired ammonium salt. The reaction is carried out in a polar aprotic solvent at room temperature, with a yield of approximately 90%.

Ammonium 4-(acetoacetylamino)-5-methoxy-2-methylbenzenesulfonate is primarily used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It is also utilized in the polymer industry as a stabilizer and in the semiconductor industry as a precursor for various applications. Additionally, it is employed in the development of sensors for detecting specific chemicals and in analytical chemistry due to its unique reactivity.

When handling Ammonium 4-(acetoacetylamino)-5-methoxy-2-methylbenzenesulfonate, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and sources of ignition. Fume hoods should be used during handling to minimize inhalation risks. In case of a spill, it is crucial to clean up immediately using appropriate absorbents and dispose of them according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and safety instructions.