3-Bromo-4-methoxypyridine(CAS: 82257-09-8)

3-Bromo-4-methoxypyridine (CAS: 82257-09-8) is a crystalline solid with a molecular weight of 220.01 g/mol. It has a low solubility in water but is soluble in organic solvents like ethanol and acetone. It is chemically reactive, particularly towards nucleophiles due to the presence of the methoxy and bromine substituents.

3-Bromo-4-methoxypyridine is typically synthesized via a multistep process involving bromination of 4-methoxypyridine followed by an acylation step. Common reagents include N-bromosuccinimide (NBS) for bromination and acetic anhydride for acylation. The process requires careful control of reaction conditions to achieve high yield and selectivity.

3-Bromo-4-methoxypyridine is used in the pharmaceutical industry for the synthesis of drugs, particularly those targeting various metabolic pathways. It is also used in the production of dyes and pigments in the chemical industry. Additionally, it finds applications in the production of semiconductor materials and as a precursor in polymer synthesis.

When handling 3-Bromo-4-methoxypyridine (CAS: 82257-09-8), it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a fume hood due to its volatility and potential for inhalation. Spills should be cleaned up with care, using absorbent material, and the area should be ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information.