3-Demethyl Colchicine-d3(CAS: 1314417-96-3)

3-Demethyl Colchicine-d3 (CAS: 1314417-96-3) is a white crystalline solid. It has a molecular weight of approximately 472.36 g/mol. The compound is poorly soluble in water but soluble in organic solvents like methanol and acetone. It is moderately reactive, especially with strong bases or reducing agents. It is stable under normal conditions but should be stored in a cool, dark place to avoid degradation.

3-Demethyl Colchicine-d3 is synthesized through a series of chemical reactions starting from colchicine. The process involves demethylation using a strong base like sodium methoxide. The reaction is carried out in an anhydrous organic solvent at low temperature. The yield is around 70%, and the method requires careful control of reaction conditions to achieve high selectivity.

3-Demethyl Colchicine-d3 (CAS: 1314417-96-3) is primarily used in the pharmaceutical industry for research purposes. It is also employed in the chemical industry for the development of new drugs and in the analytical industry for quality control and standards. In academic settings, it is used for teaching and research in organic chemistry.

When handling 3-Demethyl Colchicine-d3 (CAS: 1314417-96-3), it is important to wear appropriate personal protective equipment (PPE), including gloves, lab coat, and safety glasses. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation. Spills should be cleaned up using absorbent materials, followed by washing the area with water. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.