4,6-Dichloro-5-fluoropyrimidine(CAS: 213265-83-9)

4,6-Dichloro-5-fluoropyrimidine is a white crystalline solid with a molecular weight of approximately 217.03 g/mol. It has a solubility in water of about 11 mg/L and is highly reactive with nucleophiles. The compound is stable under normal conditions but should be protected from moisture and strong bases. It is insoluble in water but soluble in common organic solvents like ethanol and dichloromethane.

4,6-Dichloro-5-fluoropyrimidine is typically synthesized via the reaction of 5-fluorouracil with chloracetyl chloride in the presence of a base such as sodium hydroxide. The reaction yields a mixture rich in 4,6-dichloro-5-fluoropyrimidine with a high degree of selectivity. The yield is typically around 80-90%, and the method uses common laboratory equipment and standard techniques.

4,6-Dichloro-5-fluoropyrimidine is primarily used in the pharmaceutical industry, particularly in the synthesis of antitumor drugs. It is also used in the production of herbicides and in some analytical chemistry applications. Its use in polymers and semiconductors is limited but under exploration due to its unique chemical properties.

When handling 4,6-Dichloro-5-fluoropyrimidine, it is crucial to use personal protective equipment (PPE) including gloves, goggles, and a lab coat. Store the compound in a cool, dry place, away from moisture and strong bases. Always handle in a well-ventilated fume hood to minimize exposure. In case of a spill, immediately clean up with appropriate absorbents and follow the safety data sheet (SDS) for disposal instructions.