2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid(CAS: 739364-95-5)

2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid is a crystalline solid with a molecular weight of approximately 220.21 g/mol. It has a high solubility in polar solvents like DMSO and moderate solubility in water. The compound is moderately reactive, showing basic properties and can undergo acid-base reactions. It decomposes above 200°C.

2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid is commonly synthesized via the condensation of 2-methylpyrazole and 6-carboxy-1H-pyrimidine-4-one. Catalysts like p-toluenesulfonic acid (p-TSA) are used to promote the reaction. The yield is typically around 70-80%, with good selectivity towards the desired product.

2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid finds applications in pharmaceuticals, where it is used as an intermediate for drug synthesis. It is also utilized in the preparation of polymers and as a component in sensors and semiconductor materials due to its electronic properties.

When handling 2-Methylpyrazolo[1,5-a]pyrimidine-6-carboxylic acid, it is important to use personal protective equipment (PPE) such as gloves and safety goggles. It should be stored in a cool, dry place away from direct sunlight. In case of a spill, it should be handled in a fume hood. For more detailed safety information, refer to the Safety Data Sheet (SDS).