(3-Bromo-2-thienyl)boronic acid(CAS: 162607-26-3)

The (3-Bromo-2-thienyl)boronic acid (CAS: 162607-26-3) is a crystalline solid with a molecular weight of approximately 290.02 g/mol. It has a low solubility in water (0.01 g/100 mL at 25°C) but is more soluble in organic solvents like DMSO and DMF. The compound is highly reactive due to the presence of the bromine and boronic acid functionalities, making it useful in coupling reactions and other organic transformations.

The synthesis of (3-Bromo-2-thienyl)boronic acid typically involves the bromination of 2-thiophenecarboxylic acid followed by the formation of the boronic acid ester. Common methods include the use of N-bromosuccinimide (NBS) in the presence of a radical initiator, followed by a catalytic boronation step using a palladium catalyst. High selectivity and yield can be achieved under optimized conditions.

The (3-Bromo-2-thienyl)boronic acid (CAS: 162607-26-3) is primarily used in the pharmaceutical industry for the synthesis of bioactive compounds and drug intermediates. It is also employed in the preparation of polymers, sensors, and semiconductor materials due to its functional groups and reactivity.

When handling (3-Bromo-2-thienyl)boronic acid (CAS: 162607-26-3), it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation of bromine vapor. Spills should be immediately cleaned up using appropriate materials, and the area should be well-ventilated. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency procedures.