1-(4-fluorophenyl)-1H-pyrrole-2-carbaldehyde(CAS: 169036-71-9)

1-(4-fluorophenyl)-1H-pyrrole-2-carbaldehyde (CAS: 169036-71-9) is a crystalline solid with a molecular weight of approximately 243.2 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and dichloromethane. This compound is reactive due to the presence of the carbonyl group and the fluorine substituent, which can participate in various chemical reactions. It is often used in organic synthesis and medicinal chemistry.

1-(4-fluorophenyl)-1H-pyrrole-2-carbaldehyde can be synthesized via the Knoevenagel condensation of 4-fluorophenylhydrazine with pyrrole, followed by oxidation. Commonly, this condensation is catalyzed by acid, and the final oxidation step is typically performed using chromic acid or periodate. The yield and selectivity can be improved by optimizing reaction conditions, such as temperature and catalyst concentration.

1-(4-fluorophenyl)-1H-pyrrole-2-carbaldehyde (CAS: 169036-71-9) is primarily used in the pharmaceutical and chemical industries. It serves as a valuable intermediate in the synthesis of various drugs and materials. Its unique structure makes it particularly useful in the development of new materials and in the production of certain organic compounds.

Handling 1-(4-fluorophenyl)-1H-pyrrole-2-carbaldehyde (CAS: 169036-71-9) requires appropriate personal protective equipment (PPE), including gloves, lab coat, and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to volatile compounds. In case of spills, immediately clean up with appropriate materials and follow local safety guidelines. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.