7-Iodo[1,2,4]triazolo[4,3-a]pyridine(CAS: 864866-44-4)

7-Iodo[1,2,4]triazolo[4,3-a]pyridine is a crystalline solid with a molecular weight of approximately 246.15 g/mol. It has a moderate solubility in organic solvents such as DMSO and poor solubility in water. Reactivity is moderate, with potential for substitution reactions. The compound exhibits good stability under normal conditions but can be susceptible to hydrolysis in strong acids or bases.

7-Iodo[1,2,4]triazolo[4,3-a]pyridine is typically synthesized via the iodination of 1,2,4-triazolo[4,3-a]pyridine using N-iodosuccinimide (NIS) as the iodinating agent. The reaction is performed in the presence of a base such as sodium hydride. The method provides a good yield and high selectivity for the iodinated product.

7-Iodo[1,2,4]triazolo[4,3-a]pyridine is used in the pharmaceutical industry for drug synthesis due to its biological activity. It is also utilized in the polymer industry for developing functional materials and in sensor applications for its unique chemical properties.

When handling 7-Iodo[1,2,4]triazolo[4,3-a]pyridine, ensure proper personal protective equipment (PPE) including lab coat, gloves, and safety goggles. Store the compound in a dry, cool place, away from moisture and heat sources. Use appropriate ventilation when handling, and keep the container tightly closed. In case of spills, follow standard safety procedures and consult the Safety Data Sheet (SDS) for specific instructions.