Ethyl (3S)-3-hydroxy-3-phenylpropanoate(CAS: 33401-74-0)

Ethyl (3S)-3-hydroxy-3-phenylpropanoate is a colorless to slightly yellow liquid with a molecular weight of approximately 180.24 g/mol. It has a solubility of up to 12 g/L in water and is soluble in common organic solvents such as ethanol and acetone. This compound is moderately reactive, particularly towards nucleophilic attack, and is known for its reactivity in esterification reactions.

Ethyl (3S)-3-hydroxy-3-phenylpropanoate is commonly synthesized via the esterification of (3S)-3-hydroxy-3-phenylpropanoic acid with ethanol. This process often involves the use of a strong acid catalyst, such as concentrated sulfuric acid, at elevated temperatures. The yield can be improved by using a phase transfer catalyst and optimizing reaction conditions for selectivity and yield.

Ethyl (3S)-3-hydroxy-3-phenylpropanoate is primarily used in the pharmaceutical industry as an intermediate in the synthesis of certain drugs. It also finds applications in the polymer industry as a monomer for producing functionalized polymers. Additionally, it is used in the development of new sensor technologies and as a precursor in semiconductor manufacturing processes.

When handling Ethyl (3S)-3-hydroxy-3-phenylpropanoate, it is important to wear appropriate personal protective equipment (PPE), including safety goggles, gloves, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up with care, using appropriate absorbents, and the area should be thoroughly rinsed with water. Always refer to the SDS (Safety Data Sheet) for detailed information on handling and storage precautions.