(2-Fluorophenyl)(oxo)acetonitrile(CAS: 80277-41-4)

(2-Fluorophenyl)(oxo)acetonitrile is a crystalline solid with a molecular weight of approximately 183.14 g/mol. It has a melting point of around 58-59°C and is slightly soluble in water. This compound exhibits moderate reactivity, particularly towards nucleophiles and bases. It is used in organic synthesis and as a precursor in various chemical processes.

(2-Fluorophenyl)(oxo)acetonitrile can be synthesized via the reaction of 2-fluorophenylacetonitrile with an appropriate oxidizing agent. Common methods include using potassium permanganate or nitric acid as the oxidant. The reaction is known to proceed with good yield and selectivity, but precise conditions must be controlled to avoid side reactions.

(2-Fluorophenyl)(oxo)acetonitrile is used in the pharmaceutical industry for the synthesis of certain drugs. It is also utilized in organic chemistry and chemical research as a precursor in synthetic pathways. Additionally, it has applications in polymer synthesis and as a chemical reagent in analytical methods.

When handling (2-Fluorophenyl)(oxo)acetonitrile, appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. Emergency procedures and an SDS (Safety Data Sheet) should be readily available for reference in case of accidents. Storage should be in a cool, dry place away from incompatible materials.