(-)-Dipivaloyl-l-tartaric acid(CAS: 65259-81-6)

(-)-Dipivaloyl-l-tartaric acid (CAS: 65259-81-6) is a crystalline compound with a molecular weight of approximately 270.3 g/mol. It has a low solubility in water but is soluble in common organic solvents like methanol and ethanol. The compound is known for its high reactivity with various nucleophiles, particularly in esterification and aldol condensation reactions.

(-)-Dipivaloyl-l-tartaric acid (CAS: 65259-81-6) is usually synthesized via the prochiral esterification of l-tartaric acid with dipivaloyl chloride. The reaction involves the use of a catalytic amount of a Lewis acid like aluminum trichloride to promote the esterification. The process yields high enantiomeric excess of the (-)-form, with a typical yield of around 85-90%.

(-)-Dipivaloyl-l-tartaric acid (CAS: 65259-81-6) is primarily used in the pharmaceutical industry for chiral synthesis, as a chiral auxiliary in the resolution of racemic mixtures. It is also utilized in the polymer industry, particularly in the synthesis of polyesters and other polymers, and in the sensor and semiconductor industries for its chiral properties.

When handling (-)-Dipivaloyl-l-tartaric acid (CAS: 65259-81-6), it is essential to wear appropriate personal protective equipment (PPE), including safety glasses, gloves, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.