7-Amino-1,3-benzoxazol-2(3H)-one(CAS: 81282-60-2)

7-Amino-1,3-benzoxazol-2(3H)-one is a crystalline solid with a molecular weight of approximately 182.21 g/mol. It has a solubility of about 1.2 g/L in water and is slightly soluble in organic solvents. This compound is known for its moderate reactivity, particularly in nucleophilic substitution reactions.

7-Amino-1,3-benzoxazol-2(3H)-one can be synthesized via the condensation of benzaldehyde with hydrazine, followed by the oxidation of the intermediate hydrazide. Common catalysts include acid and base conditions. The overall yield is typically around 70-80%, with good selectivity for the desired product.

7-Amino-1,3-benzoxazol-2(3H)-one finds applications in pharmaceuticals, where it serves as a precursor for the synthesis of various drugs. It is also used in the production of sensors and as a component in certain polymers. Additionally, it plays a role in the development of semiconductor materials.

When handling 7-Amino-1,3-benzoxazol-2(3H)-one, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be carried out in a well-ventilated area or fume hood. In case of spills, absorb with dry sand or vermiculite and dispose of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed emergency procedures.