Oxazole-2-carboxamide(CAS: 884539-45-1)

Oxazole-2-carboxamide is a crystalline solid with a molecular weight of approximately 149.14 g/mol. It has a solubility of about 0.12 g/L in water at 25°C. Chemically, it is moderately reactive, particularly towards nucleophiles. It is stable under normal storage conditions but can decompose under basic or strongly acidic conditions.

Oxazole-2-carboxamide can be synthesized via a multi-step process, starting from oxazoles and carboxylic acids. Common methods involve condensation reactions using coupling reagents like HATU or EDC. The synthetic route can be optimized for yield and selectivity depending on desired purity and application.

Oxazole-2-carboxamide finds applications in the pharmaceutical industry as an intermediate for drug synthesis. It is also utilized in the development of sensors and in creating certain polymers. Its use in semiconductors is limited but shows potential in certain specialized applications.

When handling Oxazole-2-carboxamide, it is crucial to use appropriate personal protective equipment (PPE), including gloves and eye protection. Work should be conducted in a well-ventilated area or fume hood to minimize exposure. Spills should be cleaned up using appropriate methods, and the material safety data sheet (MSDS) should be consulted for detailed safety information.