7-Nitro-1,3-dihydro-2H-indol-2-one(CAS: 25369-31-7)

7-Nitro-1,3-dihydro-2H-indol-2-one (CAS: 25369-31-7) is a crystalline solid with a molecular weight of approximately 218.08 g/mol. It has a melting point of around 155-157°C. The compound is poorly soluble in water but soluble in organic solvents like methanol and ethanol. It exhibits good stability under normal conditions but is sensitive to strong bases and reducing agents.

7-Nitro-1,3-dihydro-2H-indol-2-one (CAS: 25369-31-7) is commonly synthesized via the nitration of indole-2-one. This process involves the reaction of indole-2-one with a nitration mixture (concentrated sulfuric acid and nitric acid) under reflux conditions. The yield is typically around 75-85%, with good selectivity for the nitro group introduction.

7-Nitro-1,3-dihydro-2H-indol-2-one (CAS: 25369-31-7) is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the chemical industry as a building block for the development of various organic compounds. Its unique chemical structure makes it valuable in the polymer industry for the synthesis of novel materials with specific properties.

When handling 7-Nitro-1,3-dihydro-2H-indol-2-one (CAS: 25369-31-7), it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. Store it in a cool, dry place away from direct sunlight and heat sources. Use a fume hood for all operations to minimize exposure to air and to control any volatilization. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.