(3S)-3-(2-Thienylsulfanyl)butanoic acid(CAS: 133359-80-5)

(3S)-3-(2-Thienylsulfanyl)butanoic acid is a white to off-white crystalline solid with a molecular weight of approximately 214.25 g/mol. It is slightly soluble in water and has a pKa of about 4.5, indicating it is a weak acid. It is reactive with bases and can undergo substitution reactions. Its solubility in organic solvents such as methanol and ethanol is moderate.

(3S)-3-(2-Thienylsulfanyl)butanoic acid can be synthesized via the reaction of 3-bromobutanoic acid with 2-thiols in the presence of a base such as potassium carbonate. The reaction is typically carried out in an aprotic solvent like dimethylformamide (DMF) at room temperature. The yield is generally moderate, and the product can be purified by recrystallization from ethanol.

(3S)-3-(2-Thienylsulfanyl)butanoic acid is used in the pharmaceutical industry for the synthesis of certain drugs, particularly those involving sulfur-containing functionalities. It can also be used in the polymer industry for the modification of polymer properties. Additionally, it has applications in the production of sensor materials and as a precursor for semiconductor materials.

When handling (3S)-3-(2-Thienylsulfanyl)butanoic acid, it is important to wear appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be carried out in a well-ventilated area or fume hood. Spills should be cleaned up with caution using appropriate cleanup materials. Always refer to the Material Safety Data Sheet (MSDS) for specific handling and storage instructions. This compound should be stored in a cool, dry place away from direct sunlight and heat sources.