2-Azabicyclo[2.2.1]heptane-3-carboxylic acid(CAS: 88260-06-4)

2-Azabicyclo[2.2.1]heptane-3-carboxylic acid is a crystalline solid with a molecular weight of approximately 185.24 g/mol. It is slightly soluble in water and has good solubility in organic solvents like ethanol and acetone. The compound exhibits moderate reactivity, particularly in condensation reactions and esterification. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight.

2-Azabicyclo[2.2.1]heptane-3-carboxylic acid can be synthesized through a multi-step process that involves the ring-opening of a lactam, followed by acidification and cyclization. Commonly, this involves aminomethylcyclohexanone, which is subjected to ring-opening with a base, followed by cyclization and acidification. The reaction conditions and catalysts used typically include mild bases and acids, with yields ranging from 50-70% depending on the optimization of the process.

2-Azabicyclo[2.2.1]heptane-3-carboxylic acid is primarily used in the pharmaceutical industry for the synthesis of various drugs and intermediates. It also finds applications in the polymer industry as a monomer for the production of functionalized polymers. Additionally, it is used in the development of sensors and semiconductors, where its unique structure provides specific functionalities.

When handling 2-Azabicyclo[2.2.1]heptane-3-carboxylic acid, it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be handled in a well-ventilated area or a fume hood. Spills should be cleaned up with appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for specific handling and disposal guidelines.