1-[(1R,4S)-7,7-Dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonamide(CAS: 72597-34-3)

1-[(1R,4S)-7,7-Dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonamide is a white crystalline solid with a molecular weight of approximately 257.39 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and ethanol. This compound is known to be chemically stable, making it a valuable reagent in organic synthesis.

1-[(1R,4S)-7,7-Dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonamide is synthesized through the methylation of 7,7-dimethylbicyclo[2.2.1]heptan-2-one using methanesulfonyl chloride in the presence of a base like triethylamine. The reaction is typically carried out in a solvent such as dichloromethane or toluene. The yield is usually around 70-80%, with good selectivity.

1-[(1R,4S)-7,7-Dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonamide is primarily used in pharmaceuticals and fine chemistry due to its unique structure and potential as a reagent. It also finds applications in polymer science for its stabilizing properties and in sensor technology for its reactivity.

Proper handling of 1-[(1R,4S)-7,7-Dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methanesulfonamide requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.