1-(2-Chloroethyl)-2-imidazolidinone(CAS: 2387-20-4)

1-(2-Chloroethyl)-2-imidazolidinone is a colorless or white crystalline solid with a molecular weight of approximately 172.61 g/mol. It has a solubility of 1.1 g/L in water and is soluble in organic solvents like ethanol and acetone. This compound is moderately reactive, particularly with nucleophiles and reducing agents. It is highly basic with a pKa of 13.2.

1-(2-Chloroethyl)-2-imidazolidinone can be synthesized through the reaction of 2-chloroethylamine with imidazolidinone. The synthesis involves condensation under basic conditions, typically using sodium hydroxide as a catalyst. The yield is generally around 85%, with high selectivity towards the desired product.

1-(2-Chloroethyl)-2-imidazolidinone is used in various industries. It is a key intermediate in the synthesis of pharmaceuticals, particularly in the production of antifungal drugs. It also finds applications in polymers as a stabilizer and in the field of sensors due to its reactivity and stability.

Handling 1-(2-Chloroethyl)-2-imidazolidinone requires caution due to its basic nature and potential for skin and eye irritation. Use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood. In case of spill, immediately clean up using appropriate absorbent materials and dispose of waste according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed information on handling and safety measures.