5-Bromo-6-methyl-1H-pyrazolo[3,4-b]pyridin-3-amine(CAS: 1211584-18-7)

5-Bromo-6-methyl-1H-pyrazolo[3,4-b]pyridin-3-amine is a crystalline solid with a molecular weight of approximately 269.04 g/mol. It is slightly soluble in water and has poor solubility in common organic solvents. This compound shows moderate reactivity with nucleophiles and can undergo substitution reactions. It is stable under normal storage conditions but should be protected from moisture and light.

5-Bromo-6-methyl-1H-pyrazolo[3,4-b]pyridin-3-amine is typically synthesized through a multi-step process involving the bromination of the corresponding methylated pyrazolo[3,4-b]pyridin-3-amine followed by reductive amination. This involves using bromine and an appropriate base, followed by a reduction step to introduce the amino functionality. The process requires careful control of reaction conditions to achieve desired selectivity and yield.

5-Bromo-6-methyl-1H-pyrazolo[3,4-b]pyridin-3-amine is used in the pharmaceutical industry for the development of new drugs. It also finds applications in the synthesis of polymers and in the production of sensors and semiconductors due to its unique chemical properties.

When handling 5-Bromo-6-methyl-1H-pyrazolo[3,4-b]pyridin-3-amine, it is important to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area or a fume hood due to its potential reactivity. Spills should be cleaned up immediately, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed safety information.