2-(Chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one(CAS: 16867-35-9)

2-(Chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one (CAS: 16867-35-9) is a white or off-white crystalline solid. Its molecular weight is approximately 244.65 g/mol. It has moderate solubility in common organic solvents like methanol and ethanol but is sparingly soluble in water. This compound is known for its good thermal stability and exhibits limited reactivity under normal conditions. It is not typically flammable or explosive.

2-(Chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one is typically synthesized via a nucleophilic substitution reaction of pyridopyrimidine-4(3H)-one with chloromethyl chlorides. The reaction is catalyzed by a Lewis acid such as aluminum trichloride. The yield is generally high, and the compound can be isolated by recrystallization from organic solvents. This synthesis method ensures good selectivity and high purity of the product.

2-(Chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one (CAS: 16867-35-9) is primarily used in the pharmaceutical and agrochemical industries for the synthesis of other compounds. It also finds applications in the development of sensors and in the preparation of certain semiconductors. Due to its unique chemical properties, it is a valuable intermediate in these fields.

When handling 2-(Chloromethyl)-4H-pyrido[1,2-a]pyrimidin-4-one (CAS: 16867-35-9), it is important to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation of fumes. In case of spill, use absorbent materials and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage.