2-nitro-1H-pyrrole(CAS: 5919-26-6)

2-nitro-1H-pyrrole (CAS: 5919-26-6) is a crystalline solid with a molecular weight of approximately 123.05 g/mol. It has a melting point of 88-89°C and is slightly soluble in water. This compound is known for its high reactivity, particularly towards nucleophiles. It is often used in organic synthesis as a precursor to other heterocycles and as a reagent in electrophilic aromatic substitution reactions.

2-nitro-1H-pyrrole can be synthesized through the nitration of pyrrole. This process involves treating pyrrole with a nitration mixture, usually consisting of concentrated nitric acid and sulfuric acid. The reaction is typically carried out under reflux to ensure complete nitration. The yield can vary depending on the reaction conditions, but it is generally around 70-85%. This method requires careful handling due to the strong acids involved.

2-nitro-1H-pyrrole (CAS: 5919-26-6) is widely used in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of various heterocyclic compounds, which are essential in the development of pharmaceuticals. Additionally, it finds applications in the preparation of organic semiconductors and as a reagent in sensors due to its reactivity and stability.

When handling 2-nitro-1H-pyrrole (CAS: 5919-26-6), it is crucial to follow strict safety protocols. Always wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Work in a well-ventilated area or a fume hood to avoid inhalation of fumes. In the event of a spill, contain the material using absorbent paper and dispose of it according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed emergency procedures and storage recommendations.