4-fluoro-1H-indazol-7-amine(CAS: 866144-03-8)

4-Fluoro-1H-indazol-7-amine (CAS: 866144-03-8) is a solid with a crystalline form. It has a molecular weight of approximately 195.16 g/mol. The compound is soluble in DMSO and slightly soluble in water. It is less reactive under normal conditions but can hydrolyze in strong acidic or basic media. It has a melting point of around 220°C and is stable under normal laboratory conditions.

4-Fluoro-1H-indazol-7-amine is generally synthesized through multistep reactions involving the condensation of 1H-indazole-7-carbaldehyde with 4-fluoroaniline, followed by reduction. The synthesis can be catalyzed by palladium-based catalysts, and the overall process provides good yield with excellent selectivity. The reaction is conducted under mild conditions to minimize side reactions.

4-Fluoro-1H-indazol-7-amine (CAS: 866144-03-8) is primarily used in the pharmaceutical industry as an intermediate for developing antifungal and antiviral drugs. It also finds applications in the sensor and semiconductor industries due to its electronic properties.

When handling 4-fluoro-1H-indazol-7-amine (CAS: 866144-03-8), appropriate personal protective equipment (PPE) should be worn, including gloves, safety goggles, and a lab coat. It should be handled in a well-ventilated area or fume hood to prevent inhalation. Spills should be carefully cleaned up using appropriate absorbent materials. Refer to the safety data sheet (SDS) for detailed information on storage and disposal.