Alpha-Estradiol(CAS: 57-91-0)

Alpha-Estradiol (CAS: 57-91-0) is a white to off-white crystalline powder with a molecular weight of approximately 276.35 g/mol. It is slightly soluble in water and ethanol, and soluble in chloroform and acetone. Chemically, it is highly reactive towards acids and bases, making it susceptible to hydrolysis and ring-opening reactions.

Alpha-Estradiol (CAS: 57-91-0) is synthesized by various methods, including reduction of estrone, hydroxylation of estrone, or direct synthesis from benzaldehyde and acetic anhydride. Common catalysts include sodium borohydride or potassium hydroxide. The reaction is typically carried out in organic solvents with high yields and good selectivity.

Alpha-Estradiol (CAS: 57-91-0) is widely used in the pharmaceutical industry for its estrogenic activity in hormone replacement therapy and contraception. It is also utilized in the synthesis of other steroid hormones and in research for studying endocrine disruptors. Additionally, it has applications in cosmetic products and as a research tool in biology and biochemistry.

When handling Alpha-Estradiol (CAS: 57-91-0), proper personal protective equipment (PPE) including gloves, goggles, and a lab coat should be worn. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately with appropriate chemicals, and the material safety data sheet (MSDS) should be consulted for detailed handling and disposal procedures.