Tert-butyl (1R,4R,5R)-2-azabicyclo[2.2.1]heptan-5-ylcarbamate(CAS: 1400808-13-0)

Tert-butyl (1R,4R,5R)-2-azabicyclo[2.2.1]heptan-5-ylcarbamate (CAS: 1400808-13-0) is a white or off-white crystalline solid with a molecular weight of approximately 247.33 g/mol. It is practically insoluble in water but soluble in organic solvents like chloroform and methanol. This compound is reactive towards nucleophiles and is prone to hydrolysis. It is often used in organic synthesis and medicinal chemistry.

Tert-butyl (1R,4R,5R)-2-azabicyclo[2.2.1]heptan-5-ylcarbamate (CAS: 1400808-13-0) is typically synthesized by the reaction of tert-butyl 4-aminocyclohexanecarboxylate with 5-bromobicyclo[2.2.1]heptan-2-one in the presence of a base such as sodium hydride. The reaction yields the target compound with good selectivity and high yield under mild conditions.

Tert-butyl (1R,4R,5R)-2-azabicyclo[2.2.1]heptan-5-ylcarbamate (CAS: 1400808-13-0) is primarily used in the pharmaceutical and fine chemical industries. It serves as a valuable intermediate in the synthesis of various biologically active compounds. Additionally, it may find applications in the polymer and sensor industries due to its chemical reactivity and structural features.

When handling Tert-butyl (1R,4R,5R)-2-azabicyclo[2.2.1]heptan-5-ylcarbamate (CAS: 1400808-13-0), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be carefully cleaned up with appropriate absorbent materials, and waste should be disposed of according to local regulations. Always refer to the safety data sheet (SDS) for detailed handling guidelines and emergency procedures.