6-Chloro-1H-indazole-3-carbonitrile(CAS: 885278-30-8)

6-Chloro-1H-indazole-3-carbonitrile (CAS: 885278-30-8) is a crystalline solid with a molecular weight of approximately 210.01 g/mol. It is slightly soluble in water and more soluble in organic solvents such as ethanol and acetone. Chemically, it is less reactive but can undergo electrophilic aromatic substitution reactions. It is often used in medicinal chemistry and as a precursor in organic synthesis.

6-Chloro-1H-indazole-3-carbonitrile is typically synthesized via electrophilic substitution reactions. One common method involves the reaction of indazole with chloroacyl chlorides in the presence of a base. The key steps include the formation of the indazole ring followed by the introduction of the chloro and cyano groups. This process requires careful control of reaction conditions to achieve high yield and selectivity.

6-Chloro-1H-indazole-3-carbonitrile (CAS: 885278-30-8) is primarily used in pharmaceuticals, where it serves as a precursor for drug development. It is also utilized in the manufacturing of organic semiconductors and as a reagent in various organic synthesis processes. Its applications in the polymer industry and sensors are less common but still relevant.

When handling 6-Chloro-1H-indazole-3-carbonitrile (CAS: 885278-30-8), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Ensure the use of a fume hood during preparation to prevent inhalation. Spills should be cleaned up carefully using appropriate absorbents, and the material should be disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed safety information.