(3aS,6aR)-4-Methoxytetrahydrofuro[3,4-b]furan-2(3H)-one(CAS: 501921-30-8)

(3aS,6aR)-4-Methoxytetrahydrofuro[3,4-b]furan-2(3H)-one is a colorless liquid with a molecular weight of approximately 144.16 g/mol. It has a moderate solubility in water and high solubility in organic solvents. The compound shows moderate reactivity, particularly towards nucleophiles and bases. It exhibits good lipophilicity, making it useful in various applications.

(3aS,6aR)-4-Methoxytetrahydrofuro[3,4-b]furan-2(3H)-one is typically synthesized via a multistep process involving the condensation of an appropriate furan derivative with methanol. The reaction is catalyzed by a metal complex, such as palladium, and proceeds with good selectivity and yield. The exact conditions and reagents may vary depending on the specific starting materials and desired purity.

(3aS,6aR)-4-Methoxytetrahydrofuro[3,4-b]furan-2(3H)-one finds applications in the pharmaceutical industry for its use as a precursor in the synthesis of biologically active compounds. It is also used in the production of sensors and semiconductors due to its unique electronic properties. Its lipophilicity makes it suitable for incorporation into polymer matrices for various industrial applications.

When handling (3aS,6aR)-4-Methoxytetrahydrofuro[3,4-b]furan-2(3H)-one, it is essential to use appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. Store the compound in a cool, well-ventilated area away from heat sources and oxidizers. Handle under a fume hood to minimize inhalation risk. In case of spill, follow standard laboratory safety protocols and refer to the Safety Data Sheet (SDS) for specific guidance.